BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.4.0.1//EN TZID:Pacific/Auckland X-WR-TIMEZONE:Pacific/Auckland BEGIN:VEVENT UID:10643@gleanreport.com DTSTART;TZID=Pacific/Auckland:20260724T120000 DTEND;TZID=Pacific/Auckland:20260724T130000 DTSTAMP:20260719T083255Z URL:https://www.gleanreport.com/events/candice-quinn/ SUMMARY:Exploring how age-related microbial dysbiosis contributes to immune remodelling and unhealthy aging. A seminar by Candice Quinn *WGTN or ONLI NE* DESCRIPTION:Malaghan Institute seminar\n\nAs the global population ages\, c hronic age-related diseases including cardiovascular disease\, cancer\, an d respiratory infection are placing an increasing burden on healthcare sys tems worldwide. A common feature of these conditions is chronic\, low-grad e inflammation ("inflammaging")\, which drives tissue dysfunction and cont ributes to the progressive loss of physiological resilience. Frailty\, a c linical syndrome characterized by diminished physiological reserve\, both predisposes individuals to these diseases and is itself a stronger predict or of disability\, hospitalization\, and mortality than chronological age. Despite its clinical importance\, the biological mechanisms that initiate unhealthy aging and frailty remain poorly understood.\n\nGrowing evidence implicates the gut microbiome as a key regulator of age-associated inflam mation and health\, yet the causal mechanisms linking microbial dysbiosis to frailty have remained elusive. In Dr. Quin's laboratory\, she and her c olleagues investigate the gut microbiome as a causal driver of unhealthy a ging. Using gnotobiotic mouse models\, they demonstrate that transplantati on of microbiota from aged donors accelerates frailty onset in germ-free r ecipients\, while defined frailty-associated microbial communities are suf ficient to induce hallmarks of immune aging and chronic inflammation. Mech anistically\, they propose that microbiota-driven inflammation promotes ep igenetic reprogramming of hematopoietic stem cells\, contributing to the d evelopment of clonal haematopoiesis of indeterminate potential (CHIP)—an age-associated condition that markedly increases the risk of cardiovascul ar disease\, blood cancer\, and severe respiratory infection. Dr Quin will present emerging evidence linking the gut microbiome to CHIP and discuss how targeting the microbiota and inflammatory pathways may provide novel t herapeutic strategies to promote healthy aging and extend healthspan.\n\nB io\nDr. Candice Quin is a Senior Lecturer in the School of Biological Scie nces at Victoria University of Wellington. Originally from Canada\, she co mpleted her PhD at the University of British Columbia before undertaking a postdoctoral fellowship at McMaster University. In 2023\, she was appoint ed Lecturer at the University of Aberdeen in Scotland\, and in May 2026 re located her research programme to Victoria University of Wellington. Dr. Q uin's research focuses on the biological mechanisms that drive immune agei ng\, with a particular focus on how the gut microbiome influences haematop oiesis and epigenetic regulation throughout the life-course. A central the me of her work is understanding the role of inflammation and a condition c alled CHIP\, and how these work together to increase the risk of blood can cers\, respiratory infections\, cardiovascular disease\, and frailty. Over all\, her goal of identifying strategies to extend healthy immune function and reduce age-related disease risk.\n\nNote that if you are coming from outside the Malaghan Institute\, please allow time to sign-in at reception for their start at 12 noon.\n\nMicrosoft Teams meeting\nJoin: https://tea ms.microsoft.com/meet/455981395684484?p=BkDX72zBTbK7tMMIay\nMeeting ID: 45 5 981 395 684 484\nPasscode: fj3jv9Wm\n\n CATEGORIES:Online,Wellington LOCATION: Seminar Room\, Malaghan Institute\, VUW\, Central Services Build ing\, Victoria University\, Wellington\, New Zealand GEO:-41.2911028;174.76845720000006 X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=Central Services Building\ , Victoria University\, Wellington\, New Zealand;X-APPLE-RADIUS=100;X-TITL E=Seminar Room\, Malaghan Institute\, VUW:geo:-41.2911028,174.768457200000 06 END:VEVENT BEGIN:VTIMEZONE TZID:Pacific/Auckland X-LIC-LOCATION:Pacific/Auckland BEGIN:STANDARD DTSTART:20260405T020000 TZOFFSETFROM:+1300 TZOFFSETTO:+1200 TZNAME:NZST END:STANDARD END:VTIMEZONE END:VCALENDAR