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UID:10621@gleanreport.com
DTSTART;TZID=Pacific/Auckland:20260717T120000
DTEND;TZID=Pacific/Auckland:20260717T120000
DTSTAMP:20260708T081845Z
URL:https://www.gleanreport.com/events/lauren-holz/
SUMMARY:Vaccines tailored for liver resident memory T cell against malaria.
  A seminar by Lauren Holz *WGTN or ONLINE*
DESCRIPTION:Malaghan Institute seminar\n\nVACCINES TAILORED FOR LIVER RESID
 ENT MEMORY T CELL AGAINST MALARIA \nDr Lauren Holz | Group Head | Universi
 ty of Melbourne \n\nVaccine-induced cytotoxic T cells can prevent malaria 
 by killing parasite-infected hepatocytes during the liver stage. While sev
 eral antigenic targets have been identified\, little consideration has bee
 n given to their temporal expression. Researchers identified SERA1 of Plas
 modium berghei as a late liver-stage target in rodent malaria and further 
 showed that the classic vaccine antigen thrombospondin-related adhesion pr
 otein (TRAP) is only an early target. While vaccination with either antige
 n alone was modestly protective\, combining these antigens enabled killing
  over the entire liver-stage\, greatly improving efficacy. Given the relat
 ively long liver-stage in human malaria\, the findings indicate that consi
 derations of temporal coverage when selecting vaccine antigens will improv
 e efficacy. \n\nDr Holz is a Group Head at the Peter Doherty Institute for
  Infection and Immunity (Doherty Institute) at the University of Melbourne
 . Dr Holz’s research focuses on developing vaccines that generate tissue
 -resident memory T cells in the liver to target malaria. In 2020\, her lab
 oratory pivoted to mRNA vaccine technologies and developed the first tissu
 e-targeted mRNA vaccine. Her work bridges fundamental immunology and trans
 lational vaccine development\, and she is currently working with industry 
 partners to advance this technology toward clinical application. \n\nNote 
 that if you are coming from outside the Malaghan Institute\, please allow 
 time to sign-in at reception for their start at 12 noon.\n\nMicrosoft Team
 s meeting\nJoin: https://teams.microsoft.com/meet/44992206759749?p=o0qhQrq
 DW4QSYDzQQW\nMeeting ID: 449 922 067 597 49\nPasscode: 9434M3t3\n
CATEGORIES:Online,Wellington
LOCATION: Seminar Room\, Malaghan Institute\, VUW\, Central  Services Build
 ing\, Victoria University\, Wellington\, New Zealand
GEO:-41.2911028;174.76845720000006
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=Central  Services Building\
 , Victoria University\, Wellington\, New Zealand;X-APPLE-RADIUS=100;X-TITL
 E=Seminar Room\, Malaghan Institute\, VUW:geo:-41.2911028,174.768457200000
 06
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